Receptor tyrosine-protein kinase ERBB3 (HER3)

HER3 (ERBB3) is a receptor tyrosine kinase and member of the EGFR/ERBB family. It functions primarily as a co-receptor due to its impaired kinase activity, forming heterodimers with other ERBB receptors like EGFR/HER1 or HER2/ERBB2 upon ligand binding (e.g., neuregulins). This heterodimerization leads to phosphorylation events and activation of downstream signaling cascades, including PI3K/AKT and MAPK/ERK, which are critical for cell growth, differentiation, and survival. Overexpression or dysregulation of HER3 is implicated in various cancers, making it an important therapeutic target.

Other names

Human epidermal growth factor receptor 3ERBB3

Monoclonal antibodies targeting the receptor or its dimerization partners.