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Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor 4 (HER4)
- Target
- HER4
- Molecular classification
- Receptor, Receptor tyrosine kinase, Single-pass type I membrane glycoprotein
01
Overview
HER4, also known as ErbB4 or ERBB4, is a receptor tyrosine kinase and a member of the epidermal growth factor receptor (EGFR/HER) family. It functions as a single-pass type I transmembrane glycoprotein with intrinsic tyrosine kinase activity. HER4 is activated by ligands like neuregulins and plays essential roles in normal development and function of various organ systems. Mutations or altered expression/activity are implicated in several diseases, including cancer and neuropsychiatric disorders. HER4 undergoes regulated intramembrane proteolysis resulting in release of two fragments: an extracellular fragment and a cytoplasmic fragment that can translocate to the nucleus to influence gene expression directly.
- Other names
- ErbB4ERBB4ALS19p180erbB4
02
Mechanism of action
Tyrosine kinase inhibition (potential)
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalCell migrationMammary gland developmentRegulation of gene expression
04
Disease associations
CancerNeuropsychiatric disordersSchizophreniaAmyotrophic lateral sclerosis
05
Safety considerations
Potential for both oncogenic and tumor suppressor roles depending on context/tissue typeComplex regulatory mechanisms involving alternative splicing/proteolytic processing/differential signaling outputs
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