Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor Type 4 (HER4)
- Target
- HER4
- Molecular classification
- Receptor Tyrosine Kinase, ErbB Family
01
Overview
Human Epidermal Growth Factor Receptor Type 4 (HER4), also known as ErbB4, is a member of the ErbB family of receptor tyrosine kinases. Upon binding to ligands like neuregulins, HER4 dimerizes and activates downstream signaling pathways involved in cell proliferation, differentiation, survival, and migration. Unlike some other ErbB family members, high HER4 expression is often associated with favorable outcomes in certain cancers, particularly breast cancer.
- Other names
- ErbB4ERBB4ERBB homolog 4ERBBHOMp180erb-bHerstatin
02
Mechanism of action
Tyrosine kinase inhibition upon ligand binding and receptor dimerization.
03
Biological functions
Cell proliferationCell differentiationCell survivalCell migrationSignal transduction
04
Disease associations
Cancer
05
Biomarkers
HER4 protein expression (high levels correlate with better prognosis in some cancers)
Beyond the preview
Go deeper on Human Epidermal Growth Factor Receptor Type 4 (HER4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Human Epidermal Growth Factor Receptor Type 4 (HER4).