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Target intelligence / Profile preview
Human Equilibrative Nucleoside Transporter 1 (hENT1)
- Target
- hENT1
- Molecular classification
- Transporter, Membrane protein
01
Overview
hENT1 is a transmembrane glycoprotein responsible for the cellular uptake of nucleosides and nucleobases, playing a crucial role in maintaining cellular nucleoside homeostasis. It is a key transporter for several cytotoxic nucleoside analogs used as chemotherapeutic agents, such as gemcitabine. hENT1 expression level is a predictive biomarker for response to gemcitabine-based chemotherapy, particularly in pancreatic cancer and sarcomas.
- Other names
- SLC29A1
02
Mechanism of action
Bidirectional transport of nucleosides across cell membranes
03
Biological functions
Nucleoside transportNucleobase transportNucleotide salvageCellular homeostasis
04
Disease associations
CancerViral infectionsBlood group system
05
Safety considerations
Drug resistance development related to hENT1 expression levelsVariability in drug response based on hENT1 polymorphisms
06
Interacting drugs
Gemcitabine
3 more in the full profile.
07
Biomarkers
hENT1 expression level (predictive marker for gemcitabine response)
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