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Target intelligence / Profile preview
Human Ether-à-go-go-Related Gene (hERG)
- Target
- hERG
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel, Inward rectifier potassium channel
01
Overview
The hERG (human Ether-à-go-go-Related Gene) channel, also known as I_Kr, is a voltage-gated inward rectifier potassium channel crucial for cardiac repolarization. Encoded by the KCNH2 gene, its protein product Kv11.1 forms a tetrameric channel that preferentially conducts potassium ions inward, shaping the action potential duration in cardiac myocytes. Dysfunction or drug-induced inhibition of hERG can lead to Long QT Syndrome and life-threatening arrhythmias.
- Other names
- KCNH2Kv11.1I_Kr
02
Mechanism of action
Drugs can inhibit hERG channel function, leading to delayed cardiac repolarization.
03
Biological functions
Cardiac repolarizationRegulation of cardiac action potential durationPotassium ion transport
04
Disease associations
Long QT SyndromeCardiac arrhythmiasTorsades de Pointes
05
Safety considerations
Drug-induced Long QT SyndromeIncreased risk of cardiac arrhythmias (Torsades de Pointes)
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