Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Human Ether-à-go-go-Related Gene potassium channel (hERG)
- Target
- hERG
- Molecular classification
- Ion channel, Voltage-gated potassium ion channel
01
Overview
The hERG channel, encoded by the KCNH2 gene, is a voltage-gated potassium ion channel crucial for cardiac action potential repolarization. Dysfunction, either through mutations or drug blockade, leads to Long QT Syndrome (LQTS) and potentially fatal arrhythmias like torsades de pointes. Its susceptibility to blockade by a wide range of drugs poses significant safety concerns during drug development.
- Other names
- KCNH2Kv11.1
02
Mechanism of action
hERG channel blockade
03
Biological functions
Regulation of cardiac action potentialCell membrane repolarization
04
Disease associations
Long QT Syndrome (LQTS)Torsades de pointesSudden cardiac death
05
Safety considerations
Drug-induced QT prolongationIncreased risk of torsades de pointesPharmacological promiscuity leading to unintended blockade
06
Biomarkers
QT interval prolongation on ECG
Beyond the preview
Go deeper on Human Ether-à-go-go-Related Gene potassium channel (hERG).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Human Ether-à-go-go-Related Gene potassium channel (hERG).