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Target intelligence / Profile preview
Human Ether-a-go-go-Related Gene potassium channel (hERG)
- Target
- hERG
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel
01
Overview
The hERG (human Ether-a-go-go-Related Gene) potassium channel is crucial for the electrical activity of the heart. It encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (I_Kr), which plays a key role in cardiac repolarization. Dysfunction or blockage of hERG can lead to Long QT Syndrome (LQTS) and sudden cardiac death. Many drugs have been withdrawn from the market due to their ability to block hERG channels, leading to dangerous arrhythmias. Understanding the structure and function of the hERG channel is crucial for developing safe drugs and for studying cardiac arrhythmias.
- Other names
- KCNH2Ether-a-go-go-related gene potassium channelI_Kr channel
02
Mechanism of action
hERG channel blockage
03
Biological functions
Cardiac repolarizationRegulation of cardiac action potential durationPotassium ion transport
04
Disease associations
Long QT Syndrome (LQTS)Cardiac arrhythmiaSudden cardiac death
05
Safety considerations
Drug-induced Long QT SyndromeArrhythmiasCardiac toxicity
06
Biomarkers
QT interval duration on ECG
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