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Target intelligence / Profile preview
Human Growth Hormone Receptor (GHR)
- Target
- GHR
- Molecular classification
- Type I/class I cytokine receptor family, Receptor
01
Overview
The human growth hormone receptor (GHR) is a transmembrane protein that mediates the effects of growth hormone (GH), playing a central role in regulating postnatal body growth, metabolism, and various physiological processes across multiple organ systems. The GHR is encoded by the GHR gene and is expressed on the surface of many cell types throughout the body. Upon GH binding, GHR activates the JAK/STAT pathway, and mutations in GHR cause Laron syndrome.
- Other names
- Growth Hormone ReceptorGH receptorGHR
02
Mechanism of action
Agonism or antagonism of GH binding, modulation of downstream signaling pathways (JAK/STAT)
03
Biological functions
Signal transductionPostnatal body growth regulationMetabolic controlRegulation of IGF-I productionGlucose homeostasisLipid metabolismBone turnoverImmune function
04
Disease associations
Laron syndrome/growth hormone insensitivity syndromeCancerGrowth disorders
05
Safety considerations
Excessive proliferative signals (cancer risk)Immune response to recombinant GHAcromegalyInsulin resistance
06
Interacting drugs
Recombinant human GH agonists
1 more in the full profile.
07
Biomarkers
GH levelsIGF-I levelsGHR mutations
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