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Target intelligence / Profile preview
Human H19 Promoter-Driven Expression (H19 Promoter)
- Target
- H19 Promoter
- Molecular classification
- Regulatory DNA element, Promoter, Non-coding RNA regulatory region
01
Overview
The human H19 promoter is a regulatory DNA sequence that controls the expression of the H19 lncRNA. It exhibits tumor-selective activity, being largely silent in most adult tissues but reactivated in many tumors. This selectivity makes it valuable for driving targeted gene expression in cancer therapy. Promoter activity is influenced by DNA methylation, histone modifications, and transcription factor binding. It should be noted, however, that despite its higher activity in tumor cells, expression does occur in normal cells, and this has to be carefully considered for therapy delivery.
- Other names
- H19 promoter regionH19 regulatory sequenceTumor-selective H19 promoter
02
Mechanism of action
N/A - This is a promoter sequence used to drive expression of therapeutic genes
03
Biological functions
Transcriptional regulationEpigenetic regulationCell proliferation (in cancer)TumorigenesisGene expression control
04
Disease associations
Cancer (tumor-selective expression)Tissue regeneration
05
Safety considerations
Potential for off-target gene expression in healthy tissues with low H19 expressionImmune response to delivered gene therapy vectorsInsertional mutagenesis if using viral vectors
06
Biomarkers
H19 promoter methylation status (predictive of promoter activity)H19 expression levels (indicator of tumor presence/activity)
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