Target intelligence / Profile preview

Human Host Proteases

Molecular classification: Enzyme, Protease, Serine protease, Cysteine protease, Metalloprotease, Aspartic protease, Threonine protease

Overview

Human host proteases are enzymes produced by human cells that catalyze the hydrolysis of peptide bonds in proteins. They play essential roles in numerous physiological processes, including protein digestion, immune response modulation, cell signaling, and tissue remodeling. Dysregulation of host protease activity is implicated in many diseases, and many viruses exploit these proteases to facilitate entry into cells, making them potential therapeutic targets.

Other names: Human cellular proteasesHost cell peptidasesHuman proteasesHuman peptidasesHost proteases

Mechanism of action

Inhibition of protease activity

Biological functions

DigestionImmune responseTissue remodelingCell signalingProtein activation/deactivationBlood coagulationFibrinolysisCiliary function regulationMucus production/clearance regulationIon transport regulation

Disease associations

Cancer metastasisInflammationNeurodegenerative diseaseViral infection

Safety considerations

Off-target effects due to broad substrate specificityPotential for disrupting essential physiological processes

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