Human ileal aminopeptidase (NAALADL1)

NAALADL1 (human ileal aminopeptidase, also called N-acetylated alpha-linked acidic dipeptidase like 1 or NAALADase L) is a zinc-dependent metallopeptidase with broad aminopeptidase activity and is highly expressed in the human small intestine, primarily in the ileal brush border membrane[1][4][7]. Unlike the closely related glutamate carboxypeptidase II, NAALADL1 lacks carboxypeptidase and dipeptidyl-peptidase IV type activities and does not act on substrates with both Pro in the P3′ position and Asp or Glu in the P2′ position[1][2][7]. Its main physiological role is associated with the final stages of protein and peptide digestion and absorption in the human digestive process[1][3][4]. It is not currently established as a direct therapeutic target, but its inhibition (e.g., by bestatin) is biochemically characterized[1][3].

Other names

N-acetylated alpha-linked acidic dipeptidase like 1NAALADASELNAALADLNAALADase LHILAP100 kDa ileum brush border membrane proteinIleal dipeptidylpeptidaseN-acetylated-alpha-linked acidic dipeptidase-like proteinileal peptidase I100human ileal aminopeptidasepeptidase homolog

Inhibition of aminopeptidase activity (e.g., bestatin inhibits NAALADL1 enzymatic function)[1][3][7]