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Human immune and tissue cells

Molecular classification
Other
01

Overview

Human immune and tissue cells represent a broad biological classification encompassing the various cell types that make up the human body and its defense systems. Immune cells, including lymphocytes and myeloid cells, are essential for the immune response, while tissue cells provide structural integrity and physiological function to organs (Alberts et al., Molecular Biology of the Cell). In pharmacology, a therapeutic target is defined as a specific molecular entity, such as a protein or nucleic acid, whose activity can be modified by a drug to produce a therapeutic effect (Overington et al., 2006, Nature Reviews Drug Discovery). Because the term 'Human immune and tissue cells' refers to a collection of diverse cellular environments rather than a specific molecule, it does not meet the criteria for a canonical therapeutic target. Drugs interact with specific receptors or enzymes located within or on the surface of these cells, rather than the cells as a whole (IUPHAR/BPS Guide to Pharmacology). Consequently, this entry is classified as incorrect for a specific molecular target database. It serves as a location for drug action rather than the target itself.

Other names
Human cellsImmune system cellsSomatic cellsTissue-resident cells
02

Mechanism of action

Not applicable as this is a cellular category, not a molecular target.

03

Biological functions

Immune responseTissue maintenanceHomeostasisCell signalingMetabolism
04

Disease associations

CancerAutoimmune diseaseInflammationInfectionDegenerative diseases
05

Safety considerations

Non-specific toxicityCytokine release syndromeOff-target tissue damageImmunosuppressionAutoimmunity

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