Human immune cells

Human immune cells, or leukocytes, are the fundamental units of the immune system, categorized into innate and adaptive lineages such as T cells, B cells, and myeloid cells (Janeway's Immunobiology, 2016). While the term 'Human immune cells' refers to a cellular category rather than a single molecular target, these cells express numerous specific proteins—like CD20 or PD-1—that serve as primary therapeutic targets in oncology and rheumatology (Nature Reviews Drug Discovery, 2018). Drugs targeting these cells aim to either enhance immunosurveillance against tumors or suppress pathological inflammation in autoimmune diseases (StatPearls, 2023). The therapeutic modulation of these cells is a cornerstone of modern medicine, though it necessitates monitoring for risks like cytokine release syndrome or opportunistic infections (NIH, 2022). Consequently, while the term is too broad for a specific molecular entry, it encompasses the cellular context for a vast array of targeted therapies. These cells are found throughout the blood, lymphatic system, and tissues, where they perform critical roles in pathogen clearance and tissue repair (PubMed, 2021). Modern biotechnology often involves the engineering of these cells, such as in CAR-T cell therapy, to provide highly specific treatments for refractory cancers (Nature, 2020).

Other names

LeukocytesWhite blood cellsImmune system cellsImmunocytes

Drugs modulate immune cell activity by binding to specific surface receptors, inhibiting intracellular signaling pathways, or neutralizing secreted cytokines to either stimulate or suppress the immune response.