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Target intelligence / Profile preview
Human Immunodeficiency Virus 1 Reverse Transcriptase (None)
- Target
- None
- Molecular classification
- Enzyme, Reverse Transcriptase
01
Overview
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is a multifunctional enzyme essential for the replication of HIV-1, the causative agent of AIDS. RT catalyzes the conversion of the viral single-stranded RNA genome into double-stranded DNA, which is then integrated into the host cell genome—a defining feature of retroviral replication. RT’s activities are critical for converting the (+)ssRNA genome packaged within virions into linear dsDNA. More than half of currently approved antiretroviral drugs target HIV-1 RT due to its essential role in viral replication.
02
Mechanism of action
Inhibition of reverse transcription
03
Biological functions
Reverse transcriptionDNA synthesisRNA degradation
04
Disease associations
Infection
05
Safety considerations
Drug resistance due to high mutation rates
06
Interacting drugs
Nevirapine
6 more in the full profile.
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