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Target intelligence / Profile preview
Human Immunodeficiency Virus Gag Gene Product (Gag)
- Target
- Gag
- Molecular classification
- Viral protein, Structural protein, Polyprotein
01
Overview
The HIV Gag gene product is a polyprotein precursor (Pr55^gag^) that is cleaved by the viral protease into several structural proteins essential for viral assembly, budding, and maturation. These include Matrix (MA), Capsid (CA), Nucleocapsid (NC), p7, p6, and spacer peptides. Gag plays a critical role in forming the viral particle and packaging the viral genome, making it an important target for antiretroviral therapies.
- Other names
- Pr55^gag^p16 (MA)Matrix proteinp24/p25 (CA)Capsid proteinp9 (NC)Nucleocapsid proteinp7p6p41
02
Mechanism of action
Inhibition of viral replication cycle stages, including assembly, budding, and maturation.
03
Biological functions
Viral assemblyViral buddingViral maturationMembrane bindingNucleic acid bindingGenome packaging
04
Disease associations
HIV infectionAIDS
05
Safety considerations
Development of drug resistancePotential for off-target effects
06
Interacting drugs
Gag gene product modulators
1 more in the full profile.
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