Target intelligence / Profile preview

Human Immunodeficiency Virus Integrase (IN)

Target: IN
Molecular classification: Enzyme, Viral protein

Overview

Human immunodeficiency virus integrase is a viral enzyme essential for the replication of HIV. Its primary function is to catalyze the insertion of viral cDNA into the host cell's genome, a critical step in establishing infection and enabling subsequent production of new virus particles

Other names: HIV IntegraseIntegrase

Mechanism of action

Inhibition of viral DNA integration into the host cell genome

Biological functions

DNA integrationViral replication

Disease associations

Infection

Safety considerations

Drug resistance

Interacting drugs

Integrase strand transfer inhibitors (INSTIs)

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