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The term "Human immunodeficiency virus type 1 antigen" generally refers to the viral proteins produced by HIV-1, which are recognized by the immune system as foreign and can be targeted in diagnostic assays or vaccine development. The most clinically relevant antigens include structural proteins such as the envelope (Env) glycoproteins (gp120 and gp41) and the capsid protein p24. These antigens play crucial roles in viral entry, replication, and immune evasion and are key targets for diagnostics and therapeutic intervention.
Varies depending on the specific antigen and drug. Entry inhibitors block viral entry by targeting gp120/gp41. Protease inhibitors prevent cleavage of viral polyproteins. Reverse transcriptase inhibitors inhibit viral replication. Integrase inhibitors prevent integration of viral DNA into host cell DNA. Attachment inhibitors prevent the virus from attaching to the host cell CD4 receptor.
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