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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 Antigen Nef (Nef)
- Target
- Nef
- Molecular classification
- Accessory protein, Viral protein
01
Overview
HIV-1 Nef is a multifunctional accessory protein crucial for viral pathogenesis. It enhances viral replication, promotes immune evasion by downregulating CD4 and MHC-I, and modulates T-cell signaling and apoptosis. Nef's ability to manipulate host cell pathways makes it a key player in HIV-1 infection and disease progression.
- Other names
- HIV-1 NefNef proteinNegative factor
02
Mechanism of action
N/A
03
Biological functions
Immune evasionViral replication enhancementT-cell modulationApoptosis regulationMembrane trafficking modulationSignal transduction modulation
04
Disease associations
HIV-1 infectionAIDSNeuropathogenesis
05
Safety considerations
Immune evasion leading to chronic infectionContribution to neuropathogenesisPotential for drug resistance through mutation
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