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Human Immunodeficiency Virus Type 1 Envelope Glycoprotein gp120 (C5 Domain) (gp120 C5 Domain)
- Target
- gp120 C5 Domain
- Molecular classification
- Glycoprotein domain, Viral protein
01
Overview
The HIV-1 envelope glycoprotein gp120 is a critical component of the viral envelope spike, responsible for mediating virus entry into host cells. The C5 domain represents the carboxy-terminal region of gp120 and plays a key role in the structure and function of the envelope protein, mediating interaction with gp41 and influencing Env maturation. It is a potential drug target for disrupting virus-cell fusion.
- Other names
- HIV-1 gp120 C5gp120 Conserved Region 5Env C5 domain
02
Mechanism of action
Disruption of Env maturation or Env-gp41 association
03
Biological functions
gp41 interactionEnv maturationViral entryMembrane fusion
04
Disease associations
InfectionHIV-1 infection
05
Safety considerations
Potential for off-target effects due to sequence similarity with host proteins
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