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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 Envelope Glycoprotein gp140 (None)
- Target
- None
- Molecular classification
- Viral protein, Envelope glycoprotein
01
Overview
HIV-1 envelope glycoprotein gp140 represents a critical component mimicking the functional viral spike's extracellular domain. It plays an essential role in virus-host cell interactions through receptor binding and membrane fusion steps mediated by its constituent subunits. Its structural fidelity when expressed recombinantly makes it invaluable both as an immunogen candidate for vaccines aiming at eliciting broadly neutralizing antibody responses against HIV/AIDS and as a tool for studying virus entry mechanisms.
- Other names
- HIV-1 gp140gp140HIV envelope glycoprotein gp140
02
Mechanism of action
N/A
03
Biological functions
Viral entryReceptor bindingMembrane fusionAntigen presentation
04
Disease associations
HIV infectionAIDS
05
Safety considerations
Potential for off-target effects when used as an immunogenGlycosylation can hinder antibody recognition
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