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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 Gag Polyprotein (Gag)
- Target
- Gag
- Molecular classification
- Structural protein, Viral protein
01
Overview
The HIV-1 Gag polyprotein is a major structural protein essential for the assembly, budding, and release of new virions from infected cells. It is encoded by the gag gene as a precursor protein (p55) and undergoes proteolytic cleavage to generate key structural components of the mature virus. Gag orchestrates virion assembly, membrane binding, genome packaging, budding, and maturation. Cleavage of Gag by the viral protease is critical for viral infectivity. Mutations within Gag can lead to antiretroviral drug resistance.
- Other names
- HIV-1 Gagp55 Gagp53 GagGroup-specific antigen polyprotein
02
Mechanism of action
Protease inhibitors prevent Gag cleavage, leading to non-infectious virions.
03
Biological functions
Virion assemblyMembrane bindingGenome packagingVirus buddingViral maturation
04
Disease associations
InfectionHIV-1 infectionAIDS
05
Safety considerations
Drug resistance due to mutations in GagMaturation inhibitors can have complex resistance profiles
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