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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 Group-specific Antigen (None)
- Target
- None
- Molecular classification
- Viral protein, Structural protein
01
Overview
The HIV-1 Gag protein (Group-specific antigen) is a polyprotein essential for virion assembly, genome packaging, and budding from the host cell membrane. It comprises several domains (MA, CA, NC, SP1, SP2, p6) that are cleaved by the viral protease during maturation to produce infectious virions. Gag is an important antiretroviral target.
- Other names
- GagPr55^Gag
02
Mechanism of action
Inhibition of virion assembly, maturation, or release
03
Biological functions
Virion assemblyGenome packagingBuddingViral replication
04
Disease associations
InfectionHIV-1 infectionAIDS
05
Safety considerations
Drug resistanceEfficacy
06
Interacting drugs
Capsid (CA) inhibitors
2 more in the full profile.
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