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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 Group-Specific Antigen Protein (Gag)
- Target
- Gag
- Molecular classification
- Viral structural protein, Polyprotein
01
Overview
The group-specific antigen (Gag) protein of human immunodeficiency virus type 1 (HIV-1) is a polyprotein that plays a central and multifaceted role in the late phase of the HIV-1 viral lifecycle. Gag is essential for viral assembly, genome packaging, and budding from the host cell. It was once considered merely a structural or scaffolding protein but is now recognized as an orchestrator of multiple critical steps in HIV-1 replication.
- Other names
- Pr55^GagMatrix protein (MA, p17)Capsid protein (CA, p24)Nucleocapsid protein (NC, p7)p6 proteinSP1SP2
02
Mechanism of action
Currently a research target; potential mechanisms of action for future drugs include inhibition of Gag multimerization, disruption of Gag-RNA interaction, interference with ESCRT recruitment, and inhibition of Gag processing.
03
Biological functions
Viral assemblyGenome packagingViral buddingMembrane targetingHost protein interactionEnv glycoprotein incorporation
04
Disease associations
InfectionHIV-1 infectionAIDS
05
Safety considerations
Drug resistanceOff-target effects on host cell proteinsPotential for immune escape
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