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Target intelligence / Profile preview
Human Immunodeficiency Virus type 1 Integrase–Lens Epithelium-Derived Growth Factor p75 Interaction
- Molecular classification
- Protein-Protein Interaction
01
Overview
The interaction between HIV-1 integrase (IN) and lens epithelium-derived growth factor p75 (LEDGF/p75) is a critical molecular event in the life cycle of HIV-1. LEDGF/p75 acts as a cellular cofactor for HIV-1 integrase, facilitating the integration of viral DNA into the host genome—a key step required for productive infection. Targeting this interaction is considered a therapeutic strategy.
02
Mechanism of action
Disruption of the HIV-1 Integrase–LEDGF/p75 interaction by binding to the LEDGF pocket on integrase.
03
Biological functions
Tethering preintegration complex to chromatinTargeting site selection during integrationHIV-1 replication
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects
06
Interacting drugs
LEDGINs
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