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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 pol Gene (HIV-1 pol)
- Target
- HIV-1 pol
- Molecular classification
- Gene, Viral Gene
01
Overview
The HIV-1 pol gene encodes the viral enzymes protease (PR), reverse transcriptase (RT), and integrase (IN), which are essential for viral replication. These enzymes are initially synthesized as part of the Gag-Pol polyprotein and are critical targets for antiretroviral therapies.
- Other names
- HIV-1 polpol geneHIV-1 polymerase gene
02
Mechanism of action
Inhibition of viral enzyme activity, preventing viral replication and maturation
03
Biological functions
Viral replicationReverse transcriptionIntegration into host genomePolyprotein processingEnzyme production
04
Disease associations
HIV-1 infectionAcquired Immunodeficiency Syndrome (AIDS)
05
Safety considerations
Drug resistance developmentAdverse drug effects of antiretroviral therapiesViral rebound upon treatment interruption
06
Interacting drugs
Protease inhibitors
2 more in the full profile.
07
Biomarkers
Viral loadDrug resistance mutations in pol geneCD4+ T cell count
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