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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 2 Protease (HIV-2 PR)
- Target
- HIV-2 PR
- Molecular classification
- Enzyme, Aspartic protease
01
Overview
Human immunodeficiency virus type 2 protease (HIV-2 PR) is an essential viral enzyme required for the maturation and infectivity of HIV-2. Like its HIV-1 counterpart, HIV-2 protease is a key target in antiretroviral therapy due to its critical role in processing viral polyproteins into functional proteins necessary for viral assembly and replication.
- Other names
- HIV2 proteaseHIV-2 Protease
02
Mechanism of action
Inhibition of HIV-2 protease blocks viral maturation, resulting in non-infectious particles.
03
Biological functions
Viral polyprotein processingViral maturationViral replication
04
Disease associations
InfectionAIDS (Acquired Immunodeficiency Syndrome)
05
Safety considerations
Drug resistanceIntrinsic resistance to some protease inhibitors
06
Interacting drugs
Darunavir
2 more in the full profile.
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