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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 2 Reverse Transcriptase (HIV-2 RT)
- Target
- HIV-2 RT
- Molecular classification
- Enzyme, Reverse Transcriptase
01
Overview
Human immunodeficiency virus type 2 reverse transcriptase (HIV-2 RT) is a multifunctional enzyme essential for the replication of HIV-2, a retrovirus responsible for AIDS. It catalyzes the conversion of viral single-stranded RNA into double-stranded DNA. HIV-2 RT is a heterodimeric protein composed of two subunits: p68 and p55. It exhibits intrinsic resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Treatment regimens must rely on other antiretroviral classes such as protease inhibitors or integrase inhibitors.
02
Mechanism of action
Reverse transcription inhibition; DNA synthesis inhibition; RNA degradation
03
Biological functions
DNA Polymerase ActivityRNase H ActivityReverse Transcription
04
Disease associations
InfectionAIDS
05
Safety considerations
Drug resistance (especially to NNRTIs)Potential for cross-resistance with other antiretroviral drugs
06
Interacting drugs
Nucleoside/nucleotide analogues
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