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Target intelligence / Profile preview
Human Immunodeficiency Virus Viral Infectivity Factor Protein (Vif)
- Target
- Vif
- Molecular classification
- Viral protein
01
Overview
The viral infectivity factor (Vif) is an accessory protein encoded by HIV-1 and HIV-2, essential for efficient viral replication in non-permissive cells. Vif counteracts the antiviral activity of APOBEC3 family proteins by inducing their ubiquitination and proteasomal degradation. It also interacts with TP53 to induce G2 cell cycle arrest. Because it antagonizes key innate immune defenses, Vif represents an attractive target for antiretroviral drug development.
02
Mechanism of action
Ubiquitin-mediated degradation of APOBEC3G/F via E3 ligase complex
03
Biological functions
Inhibition of APOBEC3G/F activityUbiquitinationProteasomal degradationG2 cell cycle arrestInhibition of autophagy
04
Disease associations
Infection
05
Safety considerations
Targeting Vif must be carefully considered to avoid unintended consequences related to immune dysregulation.Potential for off-target effects related to TP53 interaction should be investigated.
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