Human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)

Human induced pluripotent stem cell-derived cardiomyocytes are heart muscle cells generated from iPSCs by using chemical or genetic reprogramming and directed differentiation protocols involving modulation of Wnt signaling and other pathways[1][2][5]. These cells are used for disease modeling, drug toxicity testing, and potential regenerative medicine therapies, but clinical use is hampered by their relatively immature phenotype and risks such as arrhythmia and tumor formation[2][3][5]. They serve as *tools* rather than therapeutic targets, and are often identified by cardiac-specific markers like cardiac troponin T and alpha-actinin[1][2][3][5]. Summary: This entry does not describe a molecular target or receptor, but a process to generate a cell type; therefore, it is not suitable for target-based schema mapping as typically expected for drug discovery or pharmacology applications.

Other names

iPSC-derived cardiomyocytehiPSC-CMiPSC-CMPSC-derived cardiomyocyte

Not applicable (cell type, not a target; when used for drug screening, mechanisms depend on the tested drug)