Human Islet Amyloid Polypeptide Oligomer

Human islet amyloid polypeptide (hIAPP) oligomers are soluble, aggregated forms of the 37-residue peptide hormone hIAPP/amylin. These oligomers are implicated in the pathogenesis of type 2 diabetes mellitus (T2D) due to their toxicity to pancreatic β-cells. They disrupt cell membranes, induce apoptosis, and interfere with insulin secretion. The core region responsible for aggregation lies within residues 20–29. Metal ions, particularly Cu(II), can influence the oligomerization pathway and increase toxicity.

Other names

hIAPP OligomerAmylin OligomerIAPP OligomersSoluble IAPP Oligomers

Disruption of cell membranes, leading to increased permeability and/or direct lysis, particularly in pancreatic β-cells, ultimately triggering apoptosis.