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Target intelligence / Profile preview
Human Kallikrein-Related Peptidase 2 (hK2)
- Target
- hK2
- Molecular classification
- Serine protease, Kallikrein-related peptidases
01
Overview
Human kallikrein-related peptidase 2 (hK2/KLK2) is a secreted serine protease mainly produced by the prostate. It acts together with PSA/KLK3 to facilitate semen liquefaction through specific protein cleavage events. Its unique structural features—especially the flexible “99-loop”—contribute to its enzymatic specificity and regulation. Given its highly restricted expression profile, it serves as both a biological marker for prostate health/disease states and an attractive target for therapeutic intervention or diagnostic development.
- Other names
- KLK2
02
Mechanism of action
Inhibition of serine protease activity
03
Biological functions
Sperm liquefactionProteolysis
04
Disease associations
Prostate cancer
05
Biomarkers
Prostate cancer diagnosisProstate cancer prognosis
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