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Target intelligence / Profile preview
Human Leukocyte Antigen A02 (HLA-A02)
- Target
- HLA-A02
- Molecular classification
- MHC Class I, Transmembrane glycoprotein
01
Overview
HLA-A02 is a serotype within the human leukocyte antigen (HLA)-A group, a major histocompatibility complex (MHC) class I molecule. It presents peptides derived from intracellular proteins to CD8+ cytotoxic T lymphocytes, playing a critical role in immune surveillance against viruses and tumors. HLA-A02 matching is crucial in transplantation to minimize the risk of rejection. Variants within A*02 exhibit population-specific distributions.
- Other names
- HLA-A*02HLA-A2HLA-A*2
02
Biological functions
Antigen presentationT cell activationImmune responseImmune surveillance
03
Disease associations
Transplant rejectionViral infectionCancerAutoimmune diseases
04
Safety considerations
Transplant rejectionGraft-versus-host disease
05
Biomarkers
Transplant compatibilityDisease susceptibility
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