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Target intelligence / Profile preview
Human Leukocyte Antigen A1 (None)
- Target
- None
- Molecular classification
- MHC Class I transmembrane glycoprotein
01
Overview
HLA-A1 is a human leukocyte antigen (HLA) serotype within the HLA-A group, a major histocompatibility complex (MHC) class I molecule. It presents endogenous peptide antigens to CD8+ T cells, playing a crucial role in adaptive immunity and immune surveillance. While associated with some diseases through linkage disequilibrium, it's clinically relevant in transplantation due to its impact on graft survival. It is expressed on all nucleated cells.
- Other names
- HLA-A1HLA-A*01A1 antigen
02
Mechanism of action
N/A
03
Biological functions
Antigen presentationT cell activationImmune responseAdaptive immunity
04
Disease associations
Autoimmune disorders (via linkage disequilibrium)Infectious diseases (e.g., HIV)Transplant rejection
05
Safety considerations
Graft rejection in transplantationPotential for immune-mediated adverse events in disease contexts
06
Biomarkers
HLA-A1 matching in transplantation
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