Human leukocyte antigen class I histocompatibility antigen A-24 (HLA-A*24)

Human leukocyte antigen class I histocompatibility antigen A-24 (HLA-A*24) is a cell surface MHC class I protein encoded by the HLA-A gene, highly polymorphic and found on most nucleated cells. It binds short peptide fragments derived from intracellular proteins and presents them to CD8+ cytotoxic T lymphocytes, enabling immune surveillance against infected or malignant cells. The HLA-A*24 variant is one of many alleles with unique peptide-binding preferences that influence susceptibility to infectious, autoimmune, and neoplastic diseases as well as transplant outcomes[2][3][4][5][7][8].

Other names

HLA-A24MHC class I antigen HLA-A24HLA class I histocompatibility antigen, A alpha chain (A*24 variant)HLA-A*24:02 (common subtype)

Presentation of intracellular peptide antigens (including viral, tumor, and self-peptides) to CD8+ T lymphocytes, triggering immune responses[2][3][4][7].