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Target intelligence / Profile preview
Human Leukocyte Antigen DQ8 (HLA-DQ8)
- Target
- HLA-DQ8
- Molecular classification
- MHC Class II, Cell surface receptor
01
Overview
HLA-DQ8 is a human leukocyte antigen (HLA) serotype within the HLA-DQ group, which is part of the major histocompatibility complex (MHC) class II molecules. It functions as a cell surface receptor involved in presenting peptides to T cells, playing a critical role in immune system regulation and adaptive immunity. It is strongly linked to several autoimmune diseases, including Celiac Disease, Type 1 Diabetes Mellitus, and Rheumatoid Arthritis.
02
Biological functions
Antigen presentationT cell activationImmune response
03
Disease associations
Celiac DiseaseType 1 Diabetes MellitusRheumatoid ArthritisAutoimmunity
04
Safety considerations
Increased relapse rates after allogeneic stem cell transplantation
05
Biomarkers
Celiac Disease risk assessmentType 1 Diabetes Mellitus risk assessmentRheumatoid Arthritis risk assessment
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