Target intelligence / Profile preview

Human Leukocyte Antigen DR (HLA-DR)

Target: HLA-DR
Molecular classification: MHC Class II, Receptor

Overview

HLA-DR is a cell surface receptor and a member of the major histocompatibility complex (MHC) class II family. It plays a central role in the immune system by presenting peptide antigens to T-helper cells, which is crucial for initiating and regulating adaptive immune responses. Expression levels are used clinically as markers for immune competence/dysfunction. It is highly polymorphic, influencing susceptibility/resistance to various diseases.

Biological functions

Antigen presentationT-cell activationAdaptive immune responseImmune regulation

Disease associations

AutoimmunityInfection susceptibility/resistanceTransplant rejectionCancer

Biomarkers

Immune competenceImmune dysfunction

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