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Target intelligence / Profile preview
Human Leukocyte Antigen II Protein (HLA Class II)
- Target
- HLA Class II
- Molecular classification
- Receptor, Cell surface glycoprotein
01
Overview
Human leukocyte antigen class II (HLA class II) proteins are cell surface glycoproteins that present processed extracellular antigens to CD4+ T lymphocytes, initiating and regulating immune responses. They are heterodimers composed of α and β chains, with a peptide-binding groove formed by the α1 and β1 domains. HLA Class II molecules are expressed on professional antigen-presenting cells (APCs) and are crucial for adaptive immunity. Polymorphisms in HLA class II genes are associated with susceptibility to autoimmune and infectious diseases, as well as transplant rejection.
- Other names
- MHC Class IIMajor Histocompatibility Complex Class II
02
Biological functions
Antigen presentationImmune responseT cell activationB cell activationCytokine production
03
Disease associations
Autoimmune diseasesInfectious diseasesTransplant rejection
04
Safety considerations
Alloreactivity in transplantationIncreased susceptibility to certain autoimmune diseases
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