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Target intelligence / Profile preview
Human Leukocyte Elastase (HLE)
- Target
- HLE
- Molecular classification
- Enzyme, Serine protease, Endopeptidase
01
Overview
Human leukocyte elastase (HLE), also known as neutrophil elastase, is a serine protease stored in neutrophils and released during inflammation. It degrades extracellular matrix proteins and cleaves plasma proteins, playing roles in neutrophil migration, phagocytosis, tissue remodeling, and pathogen destruction. Excessive HLE activity is implicated in diseases such as emphysema, cystic fibrosis, and rheumatoid arthritis, making it a therapeutic target. Natural and synthetic inhibitors can reduce its activity.
- Other names
- Neutrophil elastaseELANEELA2Elastase 2Serine elastasePolymorphonuclear leukocyte elastaseGranulocyte elastase
02
Mechanism of action
Serine protease inhibitors bind to the active site of human leukocyte elastase, preventing it from cleaving its target proteins.
03
Biological functions
Extracellular matrix degradationProtein cleavageInnate immune responseNeutrophil migrationPhagocytosisTissue remodelingPathogen destructionModulates cell adhesion
04
Disease associations
Pulmonary emphysemaCystic fibrosisRheumatoid arthritisAtherosclerosisThoracic aortic dissectionInflammationNeutropenia
05
Safety considerations
Off-target effects of inhibitorsPotential for immune response to inhibitorsRisk of bleedingInfection
06
Interacting drugs
Alpha 1-proteinase inhibitor
4 more in the full profile.
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