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Target intelligence / Profile preview
Human Milk Fat Globule Membrane Epitope (MFGM Epitope)
- Target
- MFGM Epitope
- Molecular classification
- Glycan, Glycoprotein, Lipid, Membrane component
01
Overview
The human milk fat globule membrane (MFGM) epitope refers to specific molecular structures on the MFGM, a complex trilayered membrane surrounding lipid droplets in human milk. These epitopes, which can be carbohydrate- or protein-based, are recognized by antibodies or immune receptors and play crucial roles in immune modulation, pathogen defense, and infant gut health. The MFGM is composed of a diverse array of lipids, proteins, glycoproteins, and carbohydrates, with notable components including sphingomyelin, sialylated oligosaccharides, mucins (MUC1, MUC4), and blood group H/Lewis antigens.
- Other names
- Human MFGM EpitopeMilk Fat Globule Membrane EpitopeMFGM GlycansMFGM Proteins
02
Mechanism of action
N/A
03
Biological functions
Immune modulationPathogen decoyBarrier functionInfant gut healthNutrient delivery
04
Disease associations
Infection preventionInflammatory bowel disease (potential)Necrotizing enterocolitis (potential)
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