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Target intelligence / Profile preview
Human Papillomavirus (HPV)
- Target
- HPV
- Molecular classification
- DNA virus
01
Overview
Human Papillomavirus (HPV) is a non-enveloped, double-stranded, circular DNA virus that infects basal epithelial cells. Infection can lead to warts or, in the case of persistent infection with high-risk types, various cancers, including cervical, anal, penile, vulvar, vaginal, and oropharyngeal cancers. Vaccines are available to prevent infection by major oncogenic strains.
02
Mechanism of action
HPV vaccines stimulate the immune system to produce antibodies that neutralize HPV, preventing infection of cells.
03
Biological functions
Viral replicationCell cycle disruptionOncogenesis
04
Disease associations
Cervical cancerAnal cancerPenile cancerVulvar cancerVaginal cancerOropharyngeal cancerWarts
05
Safety considerations
Vaccine side effects (e.g., pain, swelling at injection site)Rare allergic reactions to vaccines
06
Interacting drugs
HPV vaccines (e.g., Gardasil, Cervarix)
07
Biomarkers
HPV DNAp16 expression (as a surrogate marker for HPV in some cancers)
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