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Target intelligence / Profile preview
Human Papillomavirus Capsid Protein (HPV Capsid Protein)
- Target
- HPV Capsid Protein
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The human papillomavirus (HPV) capsid is primarily composed of two structural proteins: the major capsid protein L1 and the minor capsid protein L2. L1 self-assembles into pentamers forming the icosahedral capsid protecting the viral DNA. Recombinant L1 forms virus-like particles (VLPs), the basis of prophylactic HPV vaccines. L2 assists genome encapsulation and intracellular trafficking. The capsid is essential for infection and a key target for preventative vaccines.
- Other names
- HPV capsidL1 capsid proteinL2 capsid proteinHPV virionPapillomavirus capsid
02
Mechanism of action
HPV vaccines induce neutralizing antibodies against L1 protein, preventing viral entry and infection.
03
Biological functions
Genome encapsulationHost cell attachmentImmune responseViral entryIntracellular traffickingNuclear import of viral DNA
04
Disease associations
InfectionCancer (cervical, anal, oropharyngeal, etc.)
05
Safety considerations
Potential for allergic reactions to vaccine componentsLimited efficacy against all HPV types
06
Interacting drugs
HPV vaccines (e.g., Gardasil, Cervarix)
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