Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Human Papillomavirus E6 Protein (E6)
- Target
- E6
- Molecular classification
- Oncoprotein, Viral protein, Transcription factor regulator
01
Overview
The Human papillomavirus (HPV) E6 protein is a small oncoprotein expressed by high-risk HPV strains, notably HPV-16 and HPV-18. It plays a central role in the development of cervical cancer by degrading tumor suppressors like p53, activating telomerase, modulating the immune system, and promoting cellular immortalization. E6 interacts with multiple cellular partners, including E6AP, p53, PDZ domain proteins, and BAK, to disrupt normal cell cycle control and promote malignant transformation. Targeting E6 is a major area of research for developing novel therapeutics against HPV-related cancers.
- Other names
- HPV E6E6 oncoprotein
02
Mechanism of action
Targeting E6 can restore p53 function, inhibit telomerase activity, and enhance immune recognition of infected cells. Potential mechanisms include inhibiting E6-E6AP interaction or disrupting E6 binding to other cellular targets.
03
Biological functions
p53 degradationTelomerase activationImmune modulationApoptosis inhibitionCellular immortalizationWnt signaling activation
04
Disease associations
CancerInfectionCervical cancerHPV-related malignancies
05
Safety considerations
Specificity of inhibitors to avoid off-target effectsPotential for immune-related adverse events
06
Biomarkers
E6 mRNAE6 protein expressionp16INK4a expression (surrogate marker)HPV DNA viral load
Beyond the preview
Go deeper on Human Papillomavirus E6 Protein (E6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Human Papillomavirus E6 Protein (E6).