Human Papillomavirus E7 Antigen (None)

The Human papillomavirus (HPV) E7 antigen is a multifunctional oncoprotein encoded by high-risk HPV types. It plays a central role in the viral life cycle and is critical for the oncogenic transformation of host cells, contributing to the development of cancers such as cervical cancer. E7 disrupts cell cycle regulation by binding to and degrading tumor suppressor proteins like pRb, leading to uncontrolled cell proliferation. It is a diagnostic marker and therapeutic target in HPV-associated cancers and a key component in vaccine research.

Other names

HPV E7E7 oncoproteinE7 protein

Inhibition of tumor suppressor pathways, particularly pRb; recruitment of ubiquitin ligase complexes for protein degradation; activation of E2F-mediated transcription