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Target intelligence / Profile preview
Human Papillomavirus-Infected Cell (HPV-Infected Cell)
- Target
- HPV-Infected Cell
- Molecular classification
- Cell
01
Overview
A "human papillomavirus-infected cell" refers specifically to a basal epithelial cell harboring replicating HPV genomes. These infected cells serve as reservoirs for viral persistence and propagation. Depending on host factors and specific viral genotype(s), they may remain clinically silent or progress toward benign hyperplasia or malignant transformation due to disruption of key tumor suppressor pathways.
- Other names
- HPV Infected Basal KeratinocyteHPV-transformed cellHPV-containing cell
02
Mechanism of action
Varies depending on the drug. Examples include: Inhibition of viral DNA polymerase (Cidofovir), immune stimulation (Imiquimod), cytotoxic effects (Podophyllin/Podofilox), prevention of infection (Vaccines).
03
Biological functions
Viral replicationCell proliferation (unregulated)Evasion of immune responseViral persistence
04
Disease associations
InfectionWartsCervical cancerAnal cancerVulvar cancerVaginal cancerPenile cancerOropharyngeal cancerPrecancerous lesions (e.g., high-grade squamous intraepithelial lesions)
05
Safety considerations
Risk of cancer development (high-risk HPV types)Treatment-related side effects (e.g., inflammation, skin irritation)Potential for recurrence of infectionLimited efficacy of some treatments
06
Interacting drugs
Cidofovir
5 more in the full profile.
07
Biomarkers
HPV DNA/RNA detectionp16INK4a overexpression (surrogate marker for HPV E7 activity)Ki-67 proliferation marker
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