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Target intelligence / Profile preview
Human Papillomavirus L1 Capsid Protein Type 16 (HPV16 L1)
- Target
- HPV16 L1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The L1 protein is the major capsid protein of Human papillomavirus type 16 (HPV16). It plays a central role in forming the viral capsid and in mediating infection. Recombinant expression of HPV16 L1 leads to spontaneous assembly into virus-like particles (VLPs) that closely mimic native virions but lack infectious DNA. These VLPs are highly immunogenic and form the basis for current prophylactic HPV vaccines.
- Other names
- Major Capsid ProteinStructural Protein VLPOuter Capsid ProteinVirus-like Particle (VLP)
02
Mechanism of action
L1 proteins self-assemble into virus-like particles (VLPs) that elicit a strong neutralizing antibody response, preventing HPV infection.
03
Biological functions
Capsid assemblyCell binding/entryGenome encapsulation/releaseImmunogen
04
Disease associations
CancerInfection
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