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Target intelligence / Profile preview
Human Papillomavirus L1 Capsid Protein Type 18 (L1)
- Target
- L1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The HPV18 major capsid protein L1 is essential both structurally—forming a robust protective shell around viral DNA—and functionally—mediating host cell attachment/entry. Its ability to form VLPs has enabled effective vaccine development against oncogenic HPVs like type 18 through induction of strong neutralizing antibody responses.
- Other names
- Major capsid protein L1L1
02
Mechanism of action
Vaccines containing L1 VLPs induce neutralizing antibodies that prevent HPV infection by blocking viral attachment and entry into host cells.
03
Biological functions
Viral genome encapsulationHost cell attachmentMediates cell entryVirion assembly
04
Disease associations
CancerInfection
05
Safety considerations
Potential for rare adverse reactions to HPV vaccines (e.g., injection site reactions, allergic reactions)
06
Interacting drugs
HPV vaccines (e.g., Gardasil, Cervarix)
1 more in the full profile.
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