Target intelligence / Profile preview

Human Papillomavirus L1 Protein (L1)

Target: L1
Molecular classification: Viral structural protein, Capsid protein

Overview

The Human papillomavirus (HPV) L1 protein is the major capsid protein of HPV, responsible for forming the outer shell of the virus. It self-assembles into virus-like particles (VLPs) that are highly immunogenic and form the basis for current HPV vaccines. L1 encapsulates viral DNA and mediates cell attachment. Recombinant L1 VLPs elicit strong B-cell responses, protecting against HPV infection.

Other names: HPV L1Major capsid protein L1HPV16 L1HPV18 L1

Mechanism of action

Induction of neutralizing antibodies

Biological functions

Virion assemblyGenome encapsulationCell attachmentImmune response elicitation

Disease associations

InfectionCancer (HPV-related)

Interacting drugs

HPV vaccines (Cervarix, Gardasil, Gardasil 9)

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