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Target intelligence / Profile preview
Human Papillomavirus L1 Virus-Like Particles (HPV L1 VLPs)
- Target
- HPV L1 VLPs
- Molecular classification
- Viral capsid protein, Virus-like particle, Antigen
01
Overview
Human Papillomavirus L1 Virus-Like Particles (HPV L1 VLPs) are non-infectious, self-assembled structures mimicking native HPV virions. They are used as antigens in prophylactic HPV vaccines to stimulate the human immune system, inducing high titers of neutralizing antibodies that prevent initial HPV infection and subsequent development of HPV-related diseases, including cervical cancer. The immune response involves both humoral (B cell) and cellular (T cell) immunity.
- Other names
- HPV16 L1 VLPHPV18 L1 VLPHPV L1 capsid protein VLPHPV virus-like particles
02
Mechanism of action
Stimulation of neutralizing antibody production against HPV L1 VLPs.
03
Biological functions
Antigen presentationImmune response inductionNeutralizing antibody generationB cell activationT cell activation
04
Disease associations
Cervical cancer preventionPrevention of HPV-related diseasesInfection prevention
05
Safety considerations
Injection site reactionsHypersensitivity reactionsGuillain-Barré syndrome (rare)
06
Interacting drugs
Cervarix
2 more in the full profile.
07
Biomarkers
Anti-HPV L1 antibody titersCD4+ T cell response to L1CD8+ T cell response to L1
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