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Human Papillomavirus L2 Minor Capsid Protein (None)

Target: None
Molecular classification: Viral structural protein, Viral trafficking protein

Overview

The human papillomavirus minor capsid protein L2 is a multifunctional structural component crucial for both assembly and infectivity. It mediates genome packaging within new virions as well as orchestrates complex intracellular trafficking events that deliver incoming viral DNA from endosomes all the way into host cell nuclei—a process involving multiple interactions with cellular sorting machinery. Its highly conserved regions make it an important focus for future vaccine development aimed at broader protection against diverse HPV types.

Mechanism of action

Endosome escape via CPP; retrograde transport via retromer/SNX17/COPI/dynein

Biological functions

Genome encapsidationIntracellular traffickingNuclear importViral assembly

Disease associations

InfectionCancer (HPV-associated)

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