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Target intelligence / Profile preview
Human Papillomavirus Protein E6 (E6)
- Target
- E6
- Molecular classification
- Oncoprotein, Viral protein
01
Overview
The E6 protein is an oncoprotein encoded by high-risk human papillomavirus (HPV) types, notably HPV-16 and HPV-18. It plays a central role in the induction and maintenance of cellular transformation, contributing directly to the development of cervical cancer and other HPV-associated malignancies. E6 is essential for viral replication, persistence of infection, and evasion of host cell defenses. The hallmark function of high-risk HPV E6 is targeting the tumor suppressor p53 for ubiquitin-mediated proteasomal degradation and interacts with other cellular targets.
02
Mechanism of action
Disrupt E6 interaction with E6AP/p53; Inhibit E6 interaction with PDZ domain proteins; Block E6-mediated apoptosis inhibition; Target E6 for degradation
03
Biological functions
p53 degradationApoptosis inhibitionCell cycle dysregulationEvasion of host cell defensesPDZ domain interactionCalcium signaling modulationCell adhesion modulationTranscriptional regulation modulationDNA synthesis/repair modulationSmall G-protein signaling modulationViral Replication
04
Disease associations
CancerInfectionCervical cancerHPV-associated malignancies
05
Safety considerations
Selectivity for HPV-infected cellsPotential off-target effects due to interaction with multiple host proteinsDevelopment of resistance mutations
06
Biomarkers
HPV-E6 presence/activity as biomarker for cervical neoplasia risk
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